Multiple targeted therapies have been approved by the FDA for treatment of specific cancers. Targeted cancer therapies are defined as antibody or small molecule drugs that block the growth and spread of cancer by interfering with specific cell molecules involved in tumor growth and progression. Note: Glass coverslips are preferred plastic coverslips are acceptable but will result in longer turnaround times.Īdditional Information: Cytology slides will not be returned. Specimen Type: Cytology slide (direct smears or ThinPrep)Ĭollection Instructions: Submit 1 to 3 slides stained and cover slipped with a preferred total of 5000 nucleated cells, or a minimum of at least 3000 nucleated cells. Note: The total amount of required tumor nuclei can be obtained by scraping up to 10 slides from the same block. In this document, the sizes are given as 4mm x 4mm x 10 slides as preferred: approximate/equivalent to 144 mm(2) and the minimum as 3mm x 1mm x 10 slides: approximate/equivalent to 36mm(2).Ĭollection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block with acceptable amount of tumor tissue.Ĭollection Instructions: Submit 1 slide stained with hematoxylin and eosin and 10 unstained, nonbaked slides with 5-micron thick sections of the tumor tissue. For specimen preparation guidance, see Tissue Requirement for Solid Tumor Next-Generation Sequencing in Special Instructions. Tissue fixation: 10% neutral buffered formalin, not decalcified These amounts are cumulative over up to 10 unstained slides and must have adequate percent tumor nuclei. Minimum amount of tumor area: tissue 36 mm(2) Preferred amount of tumor area with sufficient percent tumor nuclei: tissue 180 mm(2)
This assay requires at least 20% tumor nuclei. Block number-must be on all blocks, slides and paperwork (can be handwritten on the paperwork) Pathology report (final or preliminary) at minimum containing the following information must accompany specimen in order for testing to be performed:Ģ.
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